Screen Gems and Constantin Film announced today that Resident Evil 4, titled Resident Evil: Afterlife, has started production in Toronto and will be shot and released in 3-D. Series veteran Paul W.S. Anderson – who produced the recently-released Pandorum – is writing and directing the new film, taking the reigns for the first time since the original 2000 film.

Resident Evil: Afterlife is due to be released in theaters on August 27, 2010, and stars Prison Break’s Wentworth Miller, Shawn Roberts, Milla Jovovich (who returns as the ass-kicking Alice), Ali Larter from Heroes (returning as Claire), Spencer Locke, Boris Kodjoe and Jason O’Mara.

Here’s a piece of the official press release from the studio:

Actress Milla Jovovich returns as the zombie-fighting heroine Alice. Ali Larter reprises her role as Claire Redfield from Resident Evil: Extinction. Spencer Locke, who played K-Mart in “Extinction,” is also set to return. New to the film franchise is leading man Wentworth Miller, who has signed on as Chris Redfield – Claire’s brother and a popular character from the game series. Shawn Roberts will take over the role of Alice’s nemesis Wesker. Boris Kodjoe and Kim Coates have also been cast.